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Article

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.

PloS one - 1 Jan 2008

Staiger Harald, Machicao Fausto, Schäfer Silke A, Kirchhoff Kerstin, Kantartzis Konstantinos, Guthoff Martina, Silbernagel Günther, Stefan Norbert, Häring Hans-Ulrich, Fritsche Andreas

Abstract excerpt

BACKGROUND: Very recently, a novel type 2 diabetes risk gene, i.e., MTNR1B, was identified and reported to affect fasting glycemia. Using our thoroughly phenotyped cohort of subjects at an increased risk for type 2 diabetes, we assessed the association of common genetic variation within the MTNR1B locus with obesity and prediabetes traits, namely impaired insulin secretion and insulin resistance....

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Share to Blood Glucose
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glucose Tolerance Test

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Share to Insulin-Secreting Cells

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Share to Receptor, Melatonin, MT2

Source

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Identifiers

PMID: 19088850
DOI: 10.1371/journal.pone.0003962
PMCID: PMC2597741

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.PMID 19088850Read ↗

G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.Semantic proximity Read ↗

The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.Semantic proximity Read ↗

Genetic variants in MTNR1B affecting insulin secretion.Semantic proximity Read ↗

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.Semantic proximity Read ↗

A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals.Semantic proximity Read ↗

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.Semantic proximity Read ↗

A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity.Semantic proximity Read ↗

A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity.Semantic proximity Read ↗

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.Semantic proximity Read ↗

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.Semantic proximity Read ↗

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects.Semantic proximity Read ↗

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.Semantic proximity Read ↗

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