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Article

Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95.

Neuron - 8 Nov 2007

Kim Myung Jong, Futai Kensuke, Jo Jihoon, Hayashi Yasunori, Cho Kwangwook, Sheng Morgan

Abstract excerpt

The scaffold protein PSD-95 promotes the maturation and strengthening of excitatory synapses, functions that require proper localization of PSD-95 in the postsynaptic density (PSD). Here we report that phosphorylation of ser-295 enhances the synaptic accumulation of PSD-95 and the ability of PSD-95 to recruit surface AMPA receptors and potentiate excitatory postsynaptic currents. We present evidence that a...

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Source

Identifiers

PMID: 17988632
DOI: 10.1016/j.neuron.2007.09.007

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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