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Article

Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex.

Neuron - 10 Jan 2008

Saneyoshi Takeo, Wayman Gary, Fortin Dale, Davare Monika, Hoshi Naoto, Nozaki Naohito, Natsume Tohru, Soderling Thomas R

Abstract excerpt

Neuronal activity augments maturation of mushroom-shaped spines to form excitatory synapses, thereby strengthening synaptic transmission. We have delineated a Ca(2+)-signaling pathway downstream of the NMDA receptor that stimulates calmodulin-dependent kinase kinase (CaMKK) and CaMKI to promote formation of spines and synapses in hippocampal neurons. CaMKK and CaMKI form a multiprotein signaling complex with the...

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Identifiers

PMID: 18184567
DOI: 10.1016/j.neuron.2007.11.016
PMCID: PMC2277504

Genes

GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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