Article
Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.
Proceedings of the National Academy of Sciences of the United States of America - 28 May 2013
Zhu Yong-Chuan, Li Dan, Wang Lu, Lu Bin, Zheng Jing, Zhao Shi-Lin, Zeng Rong, Xiong Zhi-Qi
Abstract excerpt
The X-linked gene cyclin-dependent kinase-like 5 (CDKL5) is mutated in severe neurodevelopmental disorders, including some forms of atypical Rett syndrome, but the function and regulation of CDKL5 protein in neurons remain to be elucidated. Here, we show that CDKL5 binds to the scaffolding protein postsynaptic density (PSD)-95, and that this binding promotes the targeting of CDKL5 to excitatory synapses....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.