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Article

A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory.

Molecular and cellular neurosciences - 1 Aug 2009

Haditsch Ursula, Leone Dino P, Farinelli Mélissa, Chrostek-Grashoff Anna, Brakebusch Cord, Mansuy Isabelle M, McConnell Susan K, Palmer Theo D

Abstract excerpt

Rac1 is a member of the Rho family of small GTPases that are important for structural aspects of the mature neuronal synapse including basal spine density and shape, activity-dependent spine enlargement, and AMPA receptor clustering in vitro. Here we demonstrate that selective elimination of Rac1 in excitatory neurons in the forebrain in vivo not only affects spine structure, but also impairs synaptic plasticity...

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Identifiers

PMID: 19394428
DOI: 10.1016/j.mcn.2009.04.005
PMCID: PMC2705331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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