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Article

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

Nature cell biology - 1 Sept 2012

Ricciardi Sara, Ungaro Federica, Hambrock Melanie, Rademacher Nils, Stefanelli Gilda, Brambilla Dario, Sessa Alessandro, Magagnotti Cinzia, Bachi Angela, Giarda Elisa, Verpelli Chiara, Kilstrup-Nielsen Charlotte, Sala Carlo, Kalscheuer Vera M, Broccoli Vania

Abstract excerpt

Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome, including intellectual disability, early-onset intractable epilepsy and autism. We report here that CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disks Large Homolog 4 Protein

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Source

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Identifiers

PMID: 22922712
DOI: 10.1038/ncb2566
PMCID: PMC6485419

Genes

CDKL5
NTNG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.PMID 22922712Read ↗

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.Semantic proximity Read ↗

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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiologySemantic proximity Read ↗

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