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Article

CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.

PloS one - 1 Jan 2011

Roselli Francesco, Livrea Paolo, Almeida Osborne F X

Abstract excerpt

The early stages of Alzheimer's disease are marked by synaptic dysfunction and loss. This process results from the disassembly and degradation of synaptic components, in particular of scaffolding proteins that compose the post-synaptic density (PSD), namely PSD95, Homer and Shank. Here we investigated in rat frontal cortex dissociated culture the mechanisms involved in the downregulation of GKAP (SAPAP1), which...

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Identifiers

PMID: 21829588
DOI: 10.1371/journal.pone.0023097
PMCID: PMC3146526

Genes

PSD
CDK5

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