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Article

HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing.

Journal of biomedical science - 11 Oct 2012

Megiorni Francesca, Pizzuti Antonio

Abstract excerpt

Celiac disease (CD) is a multifactorial disorder with an estimated prevalence in Europe and USA of 1:100 and a female:male ratio of approximately 2:1. The disorder has a multifactorial etiology in which the triggering environmental factor, the gluten, and the main genetic factors, Human Leukocyte Antigen (HLA)-DQA1 and HLA-DQB1 loci, are well known. About 90-95% of CD patients carry DQ2.5 heterodimers, encoded by...

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Identifiers

PMID: 23050549
DOI: 10.1186/1423-0127-19-88
PMCID: PMC3482388

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