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Genetic susceptibilty and celiac disease: what role do HLA haplotypes play?

17 Dec 2018

Abstract excerpt

Celiac disease is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals. Many genes involved in the pathogenesis have been identified and a crucial role is known to be played by the Human Leukocyte Antigen (HLA) system. The main determinants for genetic susceptibility are HLA-DQA1 and HLA-DQB1 genes encoding for HLA-DQ2 and HLA-DQ8 molecules, carried...

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PMID: 30561391
DOI: 10.23750/abm.v89i9-s.7953

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