Article
HLA genotyping in pediatric celiac disease patients.
Bosnian journal of basic medical sciences - 16 Aug 2014
Stanković Biljana, Radlović Nedeljko, Leković Zoran, Ristić Dragana, Radlović Vladimir, Nikčević Gordana, Kotur Nikola, Vučićević Ksenija, Kostić Tatjana, Pavlović Sonja, Zukic Branka
Abstract excerpt
Celiac disease (CD) is a chronic inflammatory disease in the small intestine triggered by gluten uptake that occurs in genetically susceptible individuals. HLA-DQ2 protein encoded by HLA-DQA1*05 and DQB1*02 alleles is found in 90-95% of CD patients. All of the remaining patients carry HLA-DQ8 protein encoded by HLA-DQA1*03 and DQB1*03:02 alleles. Specific HLA-DQ genotypes define different risk for CD incidence....
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