Article
Recommendations to report and interpret HLA genetic findings in coeliac disease.
Revista espanola de enfermedades digestivas - 1 Jul 2018
Núñez Concepción, Garrote José Antonio, Arranz Eduardo, Bilbao José Ramón, Fernández Bañares Fernando, Jiménez Juana, Perucho Teresa, Ruiz Casares Eva, Sánchez-Valverde Félix, Serrano Juan I
Abstract excerpt
Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 heterodimer, specifically the DQ2.5 isoform, which is present in around 90-96% of patients of European ancestry.
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