Article
A rapid and sensitive method to detect specific human lymphocyte antigen (HLA) class II alleles associated with celiac disease.
Clinical chemistry and laboratory medicine - 1 Jan 2008
Megiorni Francesca, Mora Barbara, Bonamico Margherita, Nenna Raffaella, Di Pierro Mariarosaria, Catassi Carlo, Drago Sandro, Mazzilli Maria Cristina
Abstract excerpt
BACKGROUND: Celiac disease (CD) is a complex disorder triggered by gluten affecting genetically predisposed individuals. More than 90% of patients carry human lymphocyte antigen (HLA)-DQ2 (DQA1*05, DQB1*02) and/or HLA-DQ8 (DQA1*03, DQB1*0302). We propose the use of the DQ-CD Typing kit that allows identification of the HLA class II alleles (DQA1*0201,*03,*05, DQB1*02,*0302, DRB1*03,*04,*07) selected to be...
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