Article
The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies.
International journal of epidemiology - 1 Oct 2012
Pierce Brandon L, VanderWeele Tyler J
Abstract excerpt
BACKGROUND: Mendelian randomization (MR) studies assess the causality of associations between exposures and disease outcomes using data on genetic determinants of the exposure. In this work, we explore the effect of exposure and outcome measurement error in MR studies. METHODS: For continuous traits, we describe measurement error in terms of a theoretical regression of the measured variable on the true variable....
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