Article
Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.
Journal of human genetics - 1 Jul 2013
Tin Adrienne, Colantuoni Elizabeth, Boerwinkle Eric, Kottgen Anna, Franceschini Nora, Astor Brad C, Coresh Josef, Kao Wen Hong Linda
Abstract excerpt
Studies of multiple measures of a quantitative trait can have greater precision and thus statistical power compared with single-measure studies, but this has rarely been studied in the relation to quantitative trait measurement error models in genetic association studies. Using estimated glomerular filtration rate (eGFR), a quantitative measure of kidney function, as an example we constructed measurement error...
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