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Article

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic.

International journal of epidemiology - 1 Dec 2016

Bowden Jack, Del Greco M Fabiola, Minelli Cosetta, Davey Smith George, Sheehan Nuala A, Thompson John R

Abstract excerpt

Background: : MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments. It can be used to test for directional pleiotropy and provides an estimate of the causal effect adjusted for its presence. MR-Egger regression provides a useful additional...

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Identifiers

PMID: 27616674
DOI: 10.1093/ije/dyw220
PMCID: PMC5446088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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