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Article

Measurement Error and Power in Family-Based Extensions to Mendelian Randomization.

Behavior genetics - 1 Nov 2025

Castro-de-Araujo Luis F S, Singh Madhurbain, Zhou Yi Daniel, Vinh Philip, Maes Hermine H M, Verhulst Brad, Dolan Conor V, Neale Michael C

Abstract excerpt

Mendelian Randomization (MR) has become an important tool for causal inference in the health sciences. It takes advantage of the random segregation and independent assortment of alleles to control for background confounding factors. In brief, the method works by using genetic variants as instrumental variables, but it depends on the assumption of exclusion restriction, i.e., that the variants affect the outcome...

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Identifiers

PMID: 41182576
DOI: 10.1007/s10519-025-10236-y
PMCID: PMC12719349

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