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Article

Genetic modification of the association of paraquat and Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2012

Goldman Samuel M, Kamel Freya, Ross G Webster, Bhudhikanok Grace S, Hoppin Jane A, Korell Monica, Marras Connie, Meng Cheryl, Umbach David M, Kasten Meike, Chade Anabel R, Comyns Kathleen, Richards Marie B, Sandler Dale P, Blair Aaron, Langston J William, Tanner Caroline M

Abstract excerpt

Paraquat is one of the most widely used herbicides worldwide. It produces a Parkinson's disease (PD) model in rodents through redox cycling and oxidative stress (OS) and is associated with PD risk in humans. Glutathione transferases provide cellular protection against OS and could potentially modulate paraquat toxicity. We investigated PD risk associated with paraquat use in individuals with homozygous deletions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23045187
DOI: 10.1002/mds.25216
PMCID: PMC3572192

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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