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Article

Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1.

The American journal of clinical nutrition - 1 Sept 2011

Block Gladys, Shaikh Nishat, Jensen Christopher D, Volberg Vitaly, Holland Nina

Abstract excerpt

BACKGROUND: Glutathione S-transferases (GSTs) detoxify environmental chemicals and are involved in oxidative stress pathways. Deletion polymorphisms affect enzyme activities and have been associated with risk of disease. OBJECTIVE: The objective was to clarify whether biomarkers of oxidation, antioxidation, inflammation, and nutritional factors differ by GST genotype in healthy adults. DESIGN: Subjects (n = 383)...

Topics

Adult
Ascorbic Acid
Biomarkers
Cholesterol
Cholesterol, LDL
F2-Isoprostanes
Female
Genotype
Glutathione Transferase
Humans
Iron
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malondialdehyde

Metabolic Detoxication, Phase II

Middle Aged

Oxidative Stress

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21813807
DOI: 10.3945/ajcn.111.011460
PMCID: PMC3155929

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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