Article
Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease.
Neuroscience letters - 30 Jan 2003
Kelada Samir N, Stapleton Patricia L, Farin Federico M, Bammler Theo K, Eaton David L, Smith-Weller Terri, Franklin Gary M, Swanson Phillip D, Longstreth W T, Checkoway Harvey
Abstract excerpt
Oxidative stress is widely thought to contribute significantly to the pathogenesis Parkinson's disease (PD). Given the role of glutathione S-transferases (GSTs) in the conjugation of electrophiles and protection against reactive oxygen species, genes encoding the GSTs have been considered candidates for association studies of PD. We tested for associations between genotypes of GSTM1(homozygous deletion vs....
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