Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects.

Journal of biochemical and molecular toxicology - 1 May 2014

Jones Byron C, Huang Xuemei, Mailman Richard B, Lu Lu, Williams Robert W

Abstract excerpt

Paraquat is an herbicide used extensively in agriculture and has also been proposed to be a risk factor for Parkinson's disease. To date, experimental, clinical, and epidemiological data on paraquat neurotoxicity have been equivocal. In this short review, we discuss some technical and biological mechanisms that contribute to inconsistencies regarding paraquat neurotoxicity. We hypothesize that individual genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Botulinum Toxin and Related Neurological Disorders
Share to Environmental Pollutants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene-Environment Interaction

Share to Genetic Predisposition to Disease

Share to Herbicides

Share to Neurotoxicity Syndromes

Share to Paraquat

Share to Parkinson's Disease Mechanisms and Treatments

Source

Open in PubMed Open full text

Identifiers

PMID: 24599642
DOI: 10.1002/jbt.21552
PMCID: PMC4677573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects.PMID 24599642Read ↗

Genetic-based, differential susceptibility to paraquat neurotoxicity in mice.Semantic proximity Read ↗

Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in <i>Drosophila</i>Semantic proximity Read ↗

Paraquat exposure as an etiological factor of Parkinson's diseaseSemantic proximity Read ↗

Interaction of genetic and environmental factors in a Drosophila parkinsonism model.Semantic proximity Read ↗

Genetic basis of susceptibility to low-dose paraquat and variation between the sexes in Drosophila melanogaster.Semantic proximity Read ↗

HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers.Semantic proximity Read ↗

The Bipyridyl Herbicide Paraquat Induces Proteasome Dysfunction in Human Neuroblastoma SH-SY5Y CellsSemantic proximity Read ↗

Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson’s Disease PathophysiologySemantic proximity Read ↗

Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta.Semantic proximity Read ↗

Mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes.Semantic proximity Read ↗

Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.Semantic proximity Read ↗

Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.