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Article

Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2017

Sanders Laurie H, Paul Kimberly C, Howlett Evan H, Lawal Hakeem, Boppana Sridhar, Bronstein Jeff M, Ritz Beate, Greenamyre J Timothy

Abstract excerpt

Exposure to certain pesticides induces oxidative stress and increases Parkinson's disease (PD) risk. Mitochondrial DNA (mtDNA) damage is found in dopaminergic neurons in idiopathic PD and following pesticide exposure in experimental models thereof. Base excision repair (BER) is the major pathway responsible for repairing oxidative DNA damage in cells. Whether single nucleotide polymorphisms (SNPs) in BER genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28460087
DOI: 10.1093/toxsci/kfx086
PMCID: PMC6075191

Genes

APEX1
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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