Article
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
Current biology : CB - 6 Sept 2005
Meulener Marc, Whitworth Alexander J, Armstrong-Gold Cecilia E, Rizzu Patrizia, Heutink Peter, Wes Paul D, Pallanck Leo J, Bonini Nancy M
Abstract excerpt
Parkinson's disease (PD) is a common neurodegenerative disorder that displays both sporadic and inherited forms. Exposure to several common environmental toxins acting through oxidative stress has been shown to be associated with PD. One recently identified inherited PD gene, DJ-1, may have a role in protection from oxidative stress, thus potentially linking a genetic cause with critical environmental risk...
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