Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice.

Experimental physiology - 1 Feb 2013

Hogh K-Lynn N, Uy Christopher E, Asadi Ali, Baker Robert K, Riedel Michael J, Gray Sarah L

Abstract excerpt

Lipotoxicity is implicated in pancreatic β-cell dysfunction in obesity-induced type 2 diabetes. In vitro, activation of peroxisome proliferator-activated receptor α (PPARα) has been shown to protect pancreatic β-cells from the lipotoxic effects of palmitate, thereby preserving insulin secretion. Utilizing an adeno-associated virus (dsAAV8), overexpression of PPARα was induced specifically in pancreatic β-cells of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Dependovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Genetic Therapy

Share to Insulin

Share to Insulin Resistance

Share to Insulin-Secreting Cells

Share to PPAR alpha

Source

Identifiers

PMID: 23042378
DOI: 10.1113/expphysiol.2012.068734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice.PMID 23042378Read ↗

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.Semantic proximity Read ↗

Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase.Semantic proximity Read ↗

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies.Semantic proximity Read ↗

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.Semantic proximity Read ↗

Fatty Acid Transport Protein-2 (FATP2) Inhibition Enhances Glucose Tolerance through α-Cell-mediated GLP-1 SecretionSemantic proximity Read ↗

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in MiceSemantic proximity Read ↗

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.Semantic proximity Read ↗

Glucose-induced lipogenesis in pancreatic beta-cells is dependent on SREBP-1.Semantic proximity Read ↗

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.Semantic proximity Read ↗

Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.Semantic proximity Read ↗

Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation.Semantic proximity Read ↗

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.