Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice

26 Sept 2006

Abstract excerpt

Peroxisome proliferator-activated receptor (PPAR)gamma is a key transcription factor facilitating fat deposition in adipose tissue through its proadipogenic and lipogenic actions. Human patients with dominant-negative mutations in PPARgamma display lipodystrophy and extreme insulin resistance. For this reason it was completely unexpected that mice harboring an equivalent mutation (P465L) in PPARgamma developed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism
Share to Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17003330
DOI: 10.2337/db06-0389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in MicePMID 17003330Read ↗

Mouse models of PPAR-γ deficiency: dissecting PPAR-γ's role in metabolic homoeostasisSemantic proximity Read ↗

A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome.Semantic proximity Read ↗

Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression.Semantic proximity Read ↗

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.Semantic proximity Read ↗

Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity.Semantic proximity Read ↗

Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma.Semantic proximity Read ↗

A dominant negative PPARgamma mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility.Semantic proximity Read ↗

Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.Semantic proximity Read ↗

Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.Semantic proximity Read ↗

PPARgamma in human and mouse physiology.Semantic proximity Read ↗

Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.