Article
Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.
Circulation - 16 Nov 2004
Verreth Wim, De Keyzer Dieuwke, Pelat Michel, Verhamme Peter, Ganame Javier, Bielicki John K, Mertens Ann, Quarck Rozenn, Benhabilès Nora, Marguerie Gérard, Mackness Bharti, Mackness Mike, Ninio Ewa, Herregods Marie-Christine, Balligand Jean-Luc, Holvoet Paul
Abstract excerpt
BACKGROUND: Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown. METHODS AND RESULTS: We studied the effect of diet restrict...
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