Article
Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2013
Qi Yanfei, Chen Jinbiao, Lay Angelina, Don Anthony, Vadas Mathew, Xia Pu
Abstract excerpt
Lipotoxic stress-induced β-cell death (lipotoxicity) is recognized as a key contributor to the development of type 2 diabetes mellitus (T2DM). The current study reports a critical role of sphingosine kinase 1 (SphK1) in β-cell survival under lipotoxic conditions. In an attempt to investigate the role of SphK1 in lipotoxicity in vivo, we fed Sphk1(-/-) and wild-type (WT) mice with a high-fat diet (HFD) or normal...
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