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Article

Glucose-induced lipogenesis in pancreatic beta-cells is dependent on SREBP-1.

Molecular and cellular endocrinology - 30 Aug 2005

Sandberg Maria B, Fridriksson Jakob, Madsen Lise, Rishi Vikas, Vinson Charles, Holmsen Holm, Berge Rolf K, Mandrup Susanne

Abstract excerpt

High concentrations of glucose induce de novo fatty acid synthesis in pancreatic beta-cells and chronic exposure of elevated glucose and fatty acids synergize to induce accumulation of triglycerides, a phenomenon termed glucolipotoxicity. Here we investigate the role of sterol-regulatory element binding proteins in glucose-induced lipogenesis in the pancreatic beta-cell line INS-1E. We show that glucose induces...

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PMID: 16002205
DOI: 10.1016/j.mce.2005.05.005

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INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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