Article
Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity
16 Apr 2020
Abstract excerpt
Abstract Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lackingPparαin hepatocytes spontaneously develop steatosis without obesity in aging. Steatosis can develop into non alcoholic steatohepatitis (NASH), which may progress to irreversible damage,...