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Article

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.

Cell metabolism - 1 Feb 2005

Finck Brian N, Bernal-Mizrachi Carlos, Han Dong Ho, Coleman Trey, Sambandam Nandakumar, LaRiviere Lori L, Holloszy John O, Semenkovich Clay F, Kelly Daniel P

Abstract excerpt

The role of the peroxisome proliferator-activated receptor-alpha (PPARalpha) in the development of insulin-resistant diabetes was evaluated using gain- and loss-of-function approaches. Transgenic mice overexpressing PPARalpha in muscle (MCK-PPARalpha mice) developed glucose intolerance despite being protected from diet-induced obesity. Conversely, PPARalpha null mice were protected from diet-induced insulin...

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Identifiers

PMID: 16054054
DOI: 10.1016/j.cmet.2005.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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