Article
Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma.
BMC cancer - 5 Oct 2012
Nomoto Junko, Hiramoto Nobuhiro, Kato Motohiro, Sanada Masashi, Maeshima Akiko Miyagi, Taniguchi Hirokazu, Hosoda Fumie, Asakura Yoshitaka, Munakata Wataru, Sekiguchi Naohiro, Maruyama Dai, Watanabe Takashi, Nakagama Hitoshi, Takeuchi Kengo, Tobinai Kensei, Ogawa Seishi, Kobayashi Yukio
Abstract excerpt
BACKGROUND: The TNFAIP3 gene, which encodes a ubiquitin-modifying enzyme (A20) involved in the negative regulation of NF-κB signaling, is frequently inactivated by gene deletions/mutations in a variety of B-cell malignancies. However, the detection of this in primary Hodgkin lymphoma (HL) specimens is hampered by the scarcity of Hodgkin Reed-Sternberg (HR-S) cells even after enrichment by micro-dissection....
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