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Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma

11 Mar 2019

Abstract excerpt

Classical studies have consistently identified some specific gene mutations in classic Hodgkin lymphoma (cHL), mainly affecting members of the NF-kappaB and JAK/STAT pathways 1 , 2 , 3 , 4 . However, this knowledge is yet to be exploited in the clinical milieu. Molecular analyses of cHL have been limited because of the paucity of Hodgkin and Reed-Sternberg (HRS) cells, which usually account for < 5% of cells as...

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PMID: 30858359
DOI: 10.1038/s41408-019-0195-7

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