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Article

Suppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma.

Oncotarget - 6 Oct 2015

Lennerz Jochen K, Hoffmann Karl, Bubolz Anna-Maria, Lessel Davor, Welke Claudia, Rüther Nele, Viardot Andreas, Möller Peter

Abstract excerpt

Suppressor of cytokine signaling 1 (SOCS1) mutations are among the most frequent somatic mutations in classical Hodgkin lymphoma (cHL), yet their prognostic relevance in cHL is unexplored. Here, we performed laser-capture microdissection of Hodgkin/Reed-Sternberg (HRS) cells from tumor samples in a cohort of 105 cHL patients. Full-length SOCS1 gene sequencing showed mutations in 61% of all cases (n = 64/105)....

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Identifiers

PMID: 26336985
DOI: 10.18632/oncotarget.4829
PMCID: PMC4745714

Genes

SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Suppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma.PMID 26336985Read ↗

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