Article
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leukemia & lymphoma - 1 Sept 2006
Feuerborn Alexander, Möritz Constanze, Von Bonin Frederike, Dobbelstein Matthias, Trümper Lorenz, Stürzenhofecker Benjamin, Kube Dieter
Abstract excerpt
Classical Hodgkin's lymphoma (cHL) is a distinct malignancy of the immune system. Despite the progress made in the understanding of the pathology of cHL, the transforming events remain to be elucidated. It has been proposed that mutations in the TP53 gene in biopsy material as well as cell lines derived from cHL are rare and therefore not notably involved in the pathogenesis of the malignant H&RS cells....
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