Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel A20 (TNFAIP3) antibody (Ber-A20) can be used to detect unmutated A20 by immunohistology.

Histopathology - 1 May 2012

Hirsch Burkhard, Grünbaum Maria, Wagner Florian, Bi Yingwen, Lucka Lothar, Du Ming-Qing, Stein Harald, Dürkop Horst

Abstract excerpt

AIMS: A20 (TNFAIP3) is a nuclear factor-κB (NF-κB)-inducible component of tumour necrosis factor and Toll-like receptor intracellular signal transduction. It negatively regulates NF-κB, and has been identified as a tumour suppressor. Several studies have described A20 inactivation by deletion of the A20 locus at 6q23, inactivating mutations, and/or methylation of the A20 promoter in various lymphoma entities....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Eye Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hodgkin Disease

Share to Immunohistochemistry

Share to Intracellular Signaling Peptides and Proteins

Share to Lymphoma, Non-Hodgkin

Share to Nuclear Proteins

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Identifiers

PMID: 22393903
DOI: 10.1111/j.1365-2559.2012.04181.x

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel A20 (TNFAIP3) antibody (Ber-A20) can be used to detect unmutated A20 by immunohistology.PMID 22393903Read ↗

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas.Semantic proximity Read ↗

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.Semantic proximity Read ↗

A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma.Semantic proximity Read ↗

A20 inactivation in ocular adnexal MALT lymphomaSemantic proximity Read ↗

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.Semantic proximity Read ↗

Clinicopathologic implication of A20/TNFAIP3 deletion in diffuse large B-cell lymphoma: an analysis according to immunohistochemical subgroups and rituximab treatment.Semantic proximity Read ↗

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.Semantic proximity Read ↗

A20 (TNFAIP3) Alterations in Primary Intestinal Diffuse Large B-cell Lymphoma.Semantic proximity Read ↗

Preserving immune homeostasis with A20.Semantic proximity Read ↗

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme.Semantic proximity Read ↗

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.Semantic proximity Read ↗

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.