Article
Allelic losses on chromosome 6q25 in Hodgkin and Reed Sternberg cells.
Cancer research - 15 May 2003
Re Daniel, Starostik Petr, Massoudi Nadia, Staratschek-Jox Andrea, Dries Volker, Thomas Roman K, Diehl Volker, Wolf Jürgen
Abstract excerpt
We established a molecular cytogenetic approach to identify consistent genetic aberrations in classical Hodgkin lymphoma. Single laser-micromanipulated Hodgkin and Reed Sternberg (H-RS) cells and the respective germ line tissue were PCR-amplified using highly polymorphic microsatellite probes. Loss of heterozygosity and genomic imbalances of the fluorochrome-labeled microsatellites were determined by fragment...
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