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Article

Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype.

Biological psychiatry - 1 Mar 2013

Thambisetty Madhav, An Yang, Nalls Michael, Sojkova Jitka, Swaminathan Shanker, Zhou Yun, Singleton Andrew B, Wong Dean F, Ferrucci Luigi, Saykin Andrew J, Resnick Susan M

Abstract excerpt

BACKGROUND: The rs3818361 single nucleotide polymorphism in complement component (3b/4b) receptor-1 (CR1) is associated with increased risk of Alzheimer's disease (AD). Although this novel variant is associated with a small effect size and is unlikely to be useful as a predictor of AD risk, it might provide insights into AD pathogenesis. We examined the association between rs3818361 and brain amyloid deposition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23022416
DOI: 10.1016/j.biopsych.2012.08.015
PMCID: PMC3535537

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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