Article
Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
Brain imaging and behavior - 1 Mar 2012
Swaminathan Shanker, Shen Li, Risacher Shannon L, Yoder Karmen K, West John D, Kim Sungeun, Nho Kwangsik, Foroud Tatiana, Inlow Mark, Potkin Steven G, Huentelman Matthew J, Craig David W, Jagust William J, Koeppe Robert A, Mathis Chester A, Jack Clifford R, Weiner Michael W, Saykin Andrew J
Abstract excerpt
Amyloid imaging with [(11)C]Pittsburgh Compound-B (PiB) provides in vivo data on plaque deposition in those with, or at risk for, Alzheimer's disease (AD). We performed a gene-based association analysis of 15 quality-controlled amyloid-pathway associated candidate genes in 103 Alzheimer's Disease Neuroimaging Initiative participants. The mean normalized PiB uptake value across four brain regions known to have...
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