Article
Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
Journal of virology - 1 Dec 2012
Chopera Denis R, Cotton Laura A, Zawaira Alexander, Mann Jaclyn K, Ngandu Nobubelo K, Ntale Roman, Carlson Jonathan M, Mlisana Koleka, Woodman Zenda, de Assis Rosa Debra, Martin Eric, Miura Toshiyuki, Pereyra Florencia, Walker Bruce D, Gray Clive M, Martin Darren P, Ndung'u Thumbi, Brockman Mark A, Karim Salim Abdool, Brumme Zabrina L, Williamson Carolyn
Abstract excerpt
Certain immune-driven mutations in HIV-1, such as those arising in p24(Gag), decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. In HIV-1 subtype B, the p24(Gag) M250I mutation is a rare variant (0.6%) that is enriched among elite controllers (7.2%) (P = 0.0005) and appears to be a rare escape variant selected by...
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