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Article

Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance.

PLoS pathogens - 1 Sept 2015

Deymier Martin J, Ende Zachary, Fenton-May Angharad E, Dilernia Dario A, Kilembe William, Allen Susan A, Borrow Persephone, Hunter Eric

Abstract excerpt

Heterosexual transmission of HIV-1 is characterized by a genetic bottleneck that selects a single viral variant, the transmitted/founder (TF), during most transmission events. To assess viral characteristics influencing HIV-1 transmission, we sequenced 167 near full-length viral genomes and generated 40 infectious molecular clones (IMC) including TF variants and multiple non-transmitted (NT) HIV-1 subtype C...

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Identifiers

PMID: 26378795
DOI: 10.1371/journal.ppat.1005154
PMCID: PMC4574710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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