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Article

Impact of HLA-B*81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity

12 Jan 2012

Abstract excerpt

HIV-1 attenuation resulting from immune escape mutations selected in Gag may contribute to slower disease progression in HIV-1-infected individuals expressing certain HLA class I alleles. We previously showed that the protective allele HLA-B*81 and the HLA-B*81-selected Gag T186S mutation are strongly associated with a lower viral replication capacity of recombinant viruses encoding Gag-protease derived from...

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PMID: 22238317
DOI: 10.1128/jvi.06682-11

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