Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gag sequence variation in a human immunodeficiency virus type 1 transmission cluster influences viral replication fitness.

The Journal of general virology - 1 Feb 2013

Gijsbers Esther F, van Nuenen Ad C, Schuitemaker Hanneke, Kootstra Neeltje A

Abstract excerpt

Three men from a proven homosexual human immunodeficiency virus type 1 (HIV-1) transmission cluster showed large variation in their clinical course of infection. To evaluate the effect of evolution of the same viral variant in these three patients, we analysed sequence variation in the capsid protein and determined the impact of the observed variation on viral replication fitness in vitro. Viral gag sequences...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to gag Gene Products, Human Immunodeficiency Virus
Share to HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Mutant Proteins

Share to Mutation, Missense

Share to Sequence Analysis, DNA

Share to Suppression, Genetic

Share to Virus Replication

Source

Identifiers

PMID: 23136365
DOI: 10.1099/vir.0.048371-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gag sequence variation in a human immunodeficiency virus type 1 transmission cluster influences viral replication fitness.PMID 23136365Read ↗

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.Semantic proximity Read ↗

Extreme genetic fragility of the HIV-1 capsid.Semantic proximity Read ↗

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.Semantic proximity Read ↗

HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA IntegrationSemantic proximity Read ↗

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.Semantic proximity Read ↗

Effect of antiretroviral therapy on HIV-1 genetic evolution during acute infection.Semantic proximity Read ↗

Unusual distribution of mutations associated with serial bottleneck passages of human immunodeficiency virus type 1.Semantic proximity Read ↗

HIV-1 mutants that escape the cytotoxic T-lymphocytes are defective in viral DNA integrationSemantic proximity Read ↗

Substantial Deceleration of Adaptation of HIV-1 Within 1,500 Generations in an Experimental Evolution: A Genomic PerspectiveSemantic proximity Read ↗

Buffering deleterious polymorphisms in highly constrained parts of HIV-1 envelope by flexible regions.Semantic proximity Read ↗

Selection bias at the heterosexual HIV-1 transmission bottleneckSemantic proximity Read ↗

Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.