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Article

Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation.

Journal of clinical microbiology - 1 Mar 2005

Weber Jan, Chakraborty Bikram, Weberova Jitka, Miller Michael D, Quiñones-Mateu Miguel E

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutation K65R confers intermediate levels of resistance to several RT inhibitors, including a three- to fourfold reduction of tenofovir susceptibility. Here, we have used for the first time primary HIV-1 isolates from individuals who developed the K65R mutation while enrolled in a clinical trial of tenofovir to analyze the...

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Share to Acquired Immunodeficiency Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15750116
DOI: 10.1128/JCM.43.3.1395-1400.2005
PMCID: PMC1081293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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