Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.

doi:10.1128/JVI.00465-07

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Article

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.

Journal of virology - 1 Aug 2007

Crawford Hayley, Prado Julia G, Leslie Alasdair, Hué Stéphane, Honeyborne Isobella, Reddy Sharon, van der Stok Mary, Mncube Zenele, Brander Christian, Rousseau Christine, Mullins James I, Kaslow Richard, Goepfert Paul, Allen Susan, Hunter Eric, Mulenga Joseph, Kiepiela Photini, Walker Bruce D, Goulder Philip J R

Abstract excerpt

HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients...

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PMID: 17507468
DOI: 10.1128/JVI.00465-07
PMCID: PMC1951305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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