Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir.

Antimicrobial agents and chemotherapy - 1 Jun 2004

Grossman Zehava, Paxinos Ellen E, Averbuch Diana, Maayan Shlomo, Parkin Neil T, Engelhard Dan, Lorber Margalit, Istomin Valery, Shaked Yael, Mendelson Ella, Ram Daniela, Petropoulos Chris J, Schapiro Jonathan M

Abstract excerpt

Differences in baseline polymorphisms between subtypes may result in development of diverse mutational pathways during antiretroviral treatment. We compared drug resistance in patients with human immunodeficiency virus subtype C (referred to herein as "subtype-C-infected patients") versus subtype-B-infected patients following protease inhibitor (PI) therapy. Genotype, phenotype, and replication capacity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Viral
Share to HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Protease Inhibitors

Share to Nelfinavir

Share to RNA, Viral

Share to Viral Plaque Assay

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 15155216
DOI: 10.1128/AAC.48.6.2159-2165.2004
PMCID: PMC415604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir.PMID 15155216Read ↗

Phenotype, Genotype, and Drug Resistance in Subtype C HIV-1 Infection.Semantic proximity Read ↗

Impact of Drug Resistance-Associated Amino Acid Changes in HIV-1 Subtype C on Susceptibility to Newer Nonnucleoside Reverse Transcriptase InhibitorsSemantic proximity Read ↗

Effect of human immunodeficiency virus type 1 protease inhibitor therapy and subtype on development of resistance in subtypes B and G.Semantic proximity Read ↗

Genetic variation at NNRTI resistance-associated positions in patients infected with HIV-1 subtype C.Semantic proximity Read ↗

In vitro hypersusceptibility of human immunodeficiency virus type 1 subtype C protease to lopinavir.Semantic proximity Read ↗

Prevalence of HIV protease mutations on failure of nelfinavir-containing HAART: a retrospective analysis of four clinical studies and two observational cohorts.Semantic proximity Read ↗

Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases.Semantic proximity Read ↗

E138A in HIV-1 reverse transcriptase is more common in subtype C than B: Implications for rilpivirine use in resource-limited settingsSemantic proximity Read ↗

Description of the L76V resistance protease mutation in HIV-1 B and "non-B" subtypes.Semantic proximity Read ↗

Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.Semantic proximity Read ↗

Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen.Semantic proximity Read ↗

HIV genotype mutations evoked by nelfinavir-based regimens: frequency, background, and consequences on subsequent treatment options.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.