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Article

An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers.

PloS one - 1 Jan 2012

Savic Daniel, Bell Graeme I, Nobrega Marcelo A

Abstract excerpt

Genome-wide association studies (GWAS) have repeatedly shown an association between non-coding variants in the TCF7L2 locus and risk for type 2 diabetes (T2D), implicating a role for cis-regulatory variation within this locus in disease etiology. Supporting this hypothesis, we previously localized complex regulatory activity to the TCF7L2 T2D-associated interval using an in vivo bacterial artificial chromosome...

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Share to Chromosomes, Artificial, Bacterial
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Identifiers

PMID: 22590553
DOI: 10.1371/journal.pone.0036501
PMCID: PMC3349716

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