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Article

Development of robust hepatitis C virus genotype 4 subgenomic replicons.

Gastroenterology - 1 Jan 2013

Peng Betty, Yu Mei, Xu Simin, Lee Yu-Jen, Tian Yang, Yang Huiling, Chan Katie, Mo Hongmei, McHutchison John, Delaney William, Cheng Guofeng

Abstract excerpt

Despite the prevalence of hepatitis C virus genotype 4, no replicon system is available for study of the genotype. To facilitate discovery and development of reagents against this virus, we synthesized and transcribed a genotype 4a subgenomic replicon and transfected Huh7-Lunet cells with it, which yielded very few colonies. However, when we used a new Huh-7-derived cell line, colony formation increased ∼70-fold....

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Source

Identifiers

PMID: 23000598
DOI: 10.1053/j.gastro.2012.09.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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