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Article

Screening of hepatitis C virus inhibitors using genotype 1a HCV replicon cell lines.

Current protocols in microbiology - 1 Aug 2011

Robinson Margaret, Tian Yang, Pagratis Nikos, Delaney William E

Abstract excerpt

Hepatitis C virus (HCV) replicons are the primary tools for identifying and evaluating anti-HCV compounds during drug discovery research. Genotype 1a and 1b are the most common genotypes in North America and Europe. These genotypes display significant genetic divergence (∼20% at the nucleotide level and ∼14% at the amino acid level), which can translate into marked differences in drug susceptibility. Thus, it is...

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PMID: 21805689
DOI: 10.1002/9780471729259.mc1707s22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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