Article
Novel hepatitis C virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a.
Antimicrobial agents and chemotherapy - 1 Aug 2010
Robinson Margaret, Yang Huiling, Sun Siu-Chi, Peng Betty, Tian Yang, Pagratis Nikos, Greenstein Andrew E, Delaney William E
Abstract excerpt
The hepatitis C virus (HCV) subgenomic replicon is the primary tool for evaluating the activity of anti-HCV compounds in drug discovery research. Despite the prevalence of HCV genotype 1a (approximately 70% of U.S. HCV patients), few genotype 1a reporter replicon cell lines have been described; this is presumably due to the low replication capacity of such constructs in available Huh-7 cells. In this report, we...
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