Article
A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2013
Hamdi Salsabil, Ejghal Rajaa, Idrissi Mouna, Ezzikouri Sayeh, Hida Mohammed, Soong Lynn, Amarouch Hamid, Lemrani Meryem
Abstract excerpt
Progressive visceral leishmaniasis (VL) is fatal if not treated; yet, most infections with the causative agents are asymptomatic. We hypothesized that genetic factors contribute to this variable response to infection. The mannose-binding lectin 2 gene (MBL2) is a candidate that merits examination in the context of VL because it enhances infection with intracellular pathogens. Four functional MBL2 polymorphisms at...
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