Article
Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis.
Parasitology international - 1 Dec 2015
Mishra Anshuman, Antony Justin S, Gai Prabhanjan, Sundaravadivel Pandarisamy, Van Tong Hoang, Jha Aditya Nath, Singh Lalji, Velavan Thirumalaisamy P, Thangaraj Kumarasamy
Abstract excerpt
Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215 healthy controls from an Indian population. MBL2 functional variants were genotyped and the...
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